CORDIS Project
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This project explores how enhancers regulate gene expression during the development of fruit flies. By utilizing advanced genome analysis techniques, it aims to uncover the interactions between enhancers and promoters, providing insights into tissue differentiation and gene regulation.
Enhancers control spatio-temporal gene expression, which is central to the diversification of cell-types and tissue differentiation.
Enhancers can be located in close proximity to, or distally from, their target genes promoters, including in introns of non-cognate genes.
To regulate gene expression, distal enhancers (E) must come into proximity to interact with their promoters (P) through folding/looping of the intervening DNA.
How enhancers identify and regulate their specific target gene remai…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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