CORDIS Project
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This project explores the potential of YAP and TAZ proteins to induce stem cell characteristics in differentiated cells for regenerative medicine. By understanding the molecular networks involved, the research aims to enhance tissue regeneration and investigate the relationship between these proteins and cancer cell pl…
The possibility to artificially induce and expand in vitro tissue-specific stem cells (SCs) is an important goal for regenerative medicine, to understand organ physiology, for in vitro modeling of human diseases and many other applications.
Here we found that this goal can be achieved in the culture dish by transiently inducing expression of YAP or TAZ - nuclear effectors of the Hippo and biomechanical pathways - into primary/terminally differentiated cells of distinct tissue origins.
Moreover,…
UNIVERSITA DEGLI STUDI DI PADOVA
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Italy, Modena
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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