CORDIS Project
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This project investigates the persistence of dengue virus lineages by analyzing long-term immune responses and viral fitness. Using historical data from Thailand, it aims to understand how individual immunity evolves over decades and how various factors influence the fitness of circulating viruses.
Across pathogens, it remains unclear why some lineages persist while others die out.
Population immunity pressure coupled with relative abilities to infect and disseminate in hosts are likely to play a critical role.
There are key data and methodological gaps that prevent us from identifying and quantifying drivers of pathogen fitness.
We need robust measures of fitness and be able to apply these measures to sequences from the same ecological disease system over many years.
We also need to under…
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Singapore, Singapore
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United States, Baltimore
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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