CORDIS Project
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This project investigates the mechanism of dendro-somatic coupling in pyramidal neurons during anaesthesia, focusing on how this coupling influences neuronal signaling and feedback integration in the brain. It employs advanced techniques to study this phenomenon in both animal models and human cortical tissue.
The mechanism for anaesthesia has eluded neuroscience despite being used as a medical intervention for more than two centuries.
Two facts are clear: loss-of-consciousness under anaesthesia correlates with a massive reduction in global neuronal signalling and a de-coupling of feedback information.
We recently found that the apical dendrites of layer 5 pyramidal neurons are effectively ""cut off"" from the cell body under anaesthesia and that higher order thalamic input maintains dendro-somatic co…
HUMBOLDT-UNIVERSITAET ZU BERLIN
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FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
Greece, Irakleio
Type: Research institute
Activity type: Research Organisations
SME: No
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