CORDIS Project
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This project focuses on understanding the mechanisms of inflammation resolution in obesity-related diseases, particularly in the liver. It aims to identify processes that retain inflammatory cells and explore therapeutic strategies to restore normal inflammatory responses.
Resolution of acute inflammation, involving limiting further leukocyte recruitment, apoptosis and clearanceof inflammatory cells via macrophages as well as egress of the inflammatory cells, is operative in acuteinflammation but dysfunctional in chronic inflammatory disease.
In the latter scenario, the retention andactivation of leukocytes in the inflamed tissue linked with failure to resolve inflammation contributes toperpetuation of organ damage and loss of homeostasis.
Interestingly, persisten…
TECHNISCHE UNIVERSITAET DRESDEN
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