CORDIS Project
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This project studies the Notch signaling pathway, focusing on the dynamics of Delta ligands during endocytosis in Drosophila. It aims to clarify the mechanisms of ligand recycling and its impact on cell signaling.
The Notch (N) pathway is a highly conserved and ubiquitous signalling system involved in determining cell fate.
There is a medical relevance to understand the molecular mechanisms involved in N signalling as N dysfunction is linked to cancer, stroke and Alzheimer’s disease. N is activated by its ligands (Delta/Serrate/LAG2;DSL) expressed on adjacent cells and there is a clear correlation between ubiquitination and endocytosis for effective ligand signalling.
Although several models for DSL ligan…
FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
IDRYMA TECHNOLOGIAS KAI EREVNAS
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