CORDIS Project
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This project focuses on developing targeted nanoparticles to deliver small interfering RNAs (siRNAs) for gene silencing in hematopoietic stem cells. By targeting integrin b7 on leukocytes, the aim is to identify genes that regulate stem cell self-renewal, which could enhance therapies for inflammatory bowel diseases an…
RNA interference (RNAi) is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing.
Since the discovery that RNAi occurs in mammalian cells, RNAi has emerged as a powerful tool for elucidating gene function and identifying potential drug targets.
Harnessing RNAi holds enormous promise for therapeutic use for diseases that have proven difficult to treat with conventional drugs. RNAi can also be exogenously activated either by transducing cells with vecto…
TEL AVIV UNIVERSITY
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