CORDIS Project
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This project focuses on developing a platform to engineer liver cells in vivo, enabling the production of extracellular vesicles loaded with therapeutic RNAs and proteins. The goal is to enhance drug delivery to hard-to-reach organs, particularly the brain, using synthetic nanocarriers and cell-penetrating peptides for…
Nucleic acid-based medicines have opened a new avenue in drug discovery to target currently undruggable genes and to express therapeutic proteins, unlocking novel therapeutic options for a range of diseases, including neurodegeneration.
However, they need to be encapsulated in nanocarriers to ensure their stability and efficient uptake into cells and tissues.
Synthetic nanoparticles based on cell-penetrating peptides (CPPs) and, particularly, lipid nanoparticles (LNPs) have recently emerged as p…
KAROLINSKA INSTITUTET
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