CORDIS Project
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This project focuses on developing biocompatible hydrogels to enhance the delivery of platinum-based anticancer drugs using flavin photocatalysts. By optimizing the co-localization of these components, the project aims to improve the efficacy and control of drug release in cancer treatment.
Flavins can act as efficient photocatalysts for the conversion of Pt(IV) complexes into Pt(II) anticancer drugs such as cisplatin and carboplatin (Chem.
Sci., 2017, 8, 4619;
Angew.
Chem.
Int.
Ed., 2018, 57, 3143;
ACS Catal., 2020, 10, 187).
These unconventional catalytic reactions are bioorthogonal.
Thus, they occur with high selectivity in biological environments, with minimal off target reactions.
Nevertheless, advancing the application of this original chemistry in chemotherapy requires an op…
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