CORDIS Project
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This project focuses on developing small molecule inhibitors to study the role of lysine acetyl transferases in gene transcription regulation. By employing reverse chemical genetics and innovative cross-linkers, it aims to elucidate the interactions of these enzymes with their targets in living cells.
Small molecule modulators of protein function proved to be effective tools to elucidate the functions of newly identified proteins in reverse chemical genetic studies.
In the field of gene transcription regulation many new proteins with a poorly defined function are being discovered.
Among these proteins many enzymes are found that modulate acylation and phosphorylation.
These posttranslational modifications play an important role in cellular localization and protein-protein interactions of tran…
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