CORDIS Project
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This project aims to enhance the effectiveness of CAR-T cell therapy against solid tumors by engineering T cells to express an enzyme that removes specific sugar modifications from tumor cells. This approach targets barriers such as poor tumor recognition and an immunosuppressive environment, potentially improving canc…
T cells engineered to express tumour-specific chimeric antigen receptors (CAR) proved effective against B-cell tumours.
However, as the technology moves to solid cancers, clinical responses have not been as robust.
In this setting, several barriers need to be overcome, including poor tumour recognition and a highly immunosuppressive tumour microenvironment (TME).
Altered glycosylation is a hallmark of cancer, often manifesting as incomplete synthesis of O-glycans and increased branching of N-gly…
OSPEDALE SAN RAFFAELE SRL
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