CORDIS Project
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This project focuses on understanding acute lymphoblastic leukaemia (ALL) to identify new drug targets for therapy. It investigates the role of specific proteins in B cell development and aims to develop targeted treatments to improve outcomes for affected children.
Despite the vast improvements in survival, acute lymphoblastic leukaemia (ALL) remains one of the major causes of death in children.
The current combination chemotherapy causes acute and long-term toxicity.
Hence, there is a compelling need to understand the development of ALL and identify key players that could be used in targeted therapy.
The B cell receptor (BCR) and its precursor, pre-BCR, control the regulation of B cell differentiation and therefore aberrant pre-BCR and BCR functions resul…
UNIVERSITY OF NEWCASTLE UPON TYNE
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