CORDIS Project
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This project explores the complex interactions between bacteria and viruses by identifying and characterizing new bacterial defense systems against phages. It employs advanced genomic techniques and synthetic biology to uncover previously unknown defense mechanisms, with a focus on retrons, which produce unique RNA-DNA…
The perpetual arms race between bacteria and phage resulted in the evolution of efficient phage-resistance systems.
Such systems, including restriction enzymes and CRISPR-Cas, have a major influence on the evolution of both bacteria and phage, and have also proven invaluable as molecular tools.
We recently showed that the bacterial immune system is much richer than originally thought.
We discovered the CBASS system (Cohen, Nature 2019), prokaryotic viperins (Bernheim, Nature 2020), and additiona…
WEIZMANN INSTITUTE OF SCIENCE
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