CORDIS Project
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This project investigates how bacteria use adaptive and innate immune systems to defend against viruses, specifically bacteriophages. By exploring the mechanisms of these defense systems, the research aims to uncover new genetic tools and therapeutic strategies for combating antibiotic-resistant pathogens.
Microbes are engaged in an evolutionary arms-race with their viruses and have evolved a spectrum of adaptive and innate defense systems to limit viral predation.
Mechanistic insights into defense systems have yielded truly revolutionary genetic tools ranging from CRISPR-based genome editing nucleases to restriction enzymes used for molecular cloning.
Despite the ongoing effort to understand defense systems, many antiviral defense systems remain virtually unstudied in and outside their native mic…
TECHNISCHE UNIVERSITEIT DELFT
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