CORDIS Project
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This project investigates how cannabinoid type-1 receptors in the brain influence the balance between active and passive defensive behaviors in response to threats. By studying genetically modified mice, the research aims to uncover mechanisms that may contribute to anxiety and post-traumatic stress disorders.
Defensive behaviours are fundamental for survival.
Due to threat diversity, organisms adopt active (e.g. escape) or passive (e.g. freeze) defensive strategies to respond accordingly.
The balance between active and passive responses can be defined as ""Active-Passive Trade-off"" (APT) and disruptions in this process may trigger maladaptive behaviours underlying anxiety and post-traumatic stress conditions, the most common psychiatric disorders in humans.
Despite the abundant literature on defensi…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Bordeaux
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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