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DeepScalePPIs aims to understand protein-protein interactions by quantifying the effects of millions of mutations. The project will generate a large dataset to improve predictions of binding affinity, aiding in drug development and biotechnology applications.
Understanding, predicting and engineering protein-protein interaction (PPI) affinity and specificity is a key problem in molecular biology.
In particular, we do not know how sequence-to-affinity encoding works at a quantitative and mechanistic level and we cannot predict and engineer the effects of mutations on PPIs.
To tackle this problem, we need to generate large amounts of quantitative biophysical measurements.
Until now this was not possible due to the low throughput of classic biophysics t…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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