CORDIS Project
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DeepGenetics aims to enhance our understanding of genetic regulation in human cells by analyzing genetic networks at the protein and amino acid levels. The project seeks to uncover hidden biological processes that influence cellular traits, using advanced genetic tools and modifier screens to reveal new cellular pathwa…
Human genes are organized in complex networks, to produce thousands of proteins to perform a myriad of functions.
Whereas we have detailed maps for most biochemical pathways, the wiring of genetic networks in human cells is poorly understood.Development of powerful human genetic tools (CRISPR, RNAi, haploid cells), to which I made crucial contributions, have proven invaluable to study genetic networks.
However, they face two major limitations.
First, they provide information at the gene level, w…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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