CORDIS Project
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This project investigates the role of intrinsically disordered regions in the formation and stability of biomolecular condensates using the yeast prion [SMAUG+]. By applying deep mutagenesis scans to the RNA binding protein Vts1, the project aims to uncover mechanisms of prion activity and develop predictive models for…
Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes despite their poor evolutionary conservation. IDRs have recently gained considerable interest as drivers of the formation of biomolecular condensates, representing a novel fundamental principle of eukaryotic subcellular organization.
However, a detailed mechanistic description of how intra and intermolecular interactions drive the formation, stability and physical properties of condensates is lacking.In this project, w…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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