CORDIS Project
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This project investigates the effects of crosslinking damage on RNA and proteins within cells, aiming to understand how such damage influences cellular health. By developing experimental models, it seeks to uncover the mechanisms that detect and repair this damage, with implications for cancer therapy and aging.
Cells are constantly challenged by complex crosslinking damage, which is caused not only by endogenous metabolites, such as reactive aldehydes, but also by various exogenous sources.
While crosslinking damage to DNA has been studied extensively, almost all reactive agents act pleiotropically and also damage RNA and proteins.
However, due to the complexity of the damage, it is difficult to determine which components of the damage are responsible for specific cellular outcomes.
Therefore, it is un…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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