CORDIS Project
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This project investigates the role of small ubiquitin-like modifiers in cellular processes, particularly how they interact with other modifications to maintain genome integrity. Using advanced mass spectrometry, it aims to uncover specific signaling pathways that protect against diseases like cancer and neurodegenerati…
Functional activity of proteins is tightly controlled via reversible post-translational modifications including phosphorylation, acetylation and ubiquitylation.
These modifications enable the orchestration of cellular responses to a wide variety of stimuli.
Due to these modifications, proteomes are overwhelmingly complex.
Progress in the field has been greatly accelerated by the development of novel approaches to study these post-translational modifications at a proteome-wide scale using the sen…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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