CORDIS Project
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This project investigates the role of large intervening non-coding RNAs (lincRNAs) in cancer, specifically focusing on acute promyelocytic leukaemia. By analyzing lincRNA expression during treatment with all-trans retinoic acid, the project aims to uncover their impact on gene regulation and epigenetic changes associat…
Increasing evidence indicates that non coding RNAs play a major role in the regulation of gene expression. A significant fraction of the non-coding transcriptome is represented by large intervening non coding RNA (lincRNAs), which seem to be involved with the epigenetic control of gene expression through binding with several members of the Polycomb Repressive Complexes (PRCs).
Recently, dysregulation of lincRNAs has been associated to cancer.
The HOTAIR lincRNA triggers the invasive program of b…
UNIVERSITA DEGLI STUDI DI TORINO
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