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DECODEM studies how a cell's history of division affects its aging process, particularly in muscle stem cells. The project aims to uncover the mechanisms of cellular aging and explore potential interventions to maintain cell identity and function over time.
Maintaining cell identity is crucial for multicellular organisms; yet this “cellular memory” is potentially compromised each time a cell divides.
To date, the degree to which sustained proliferation contributes to the accumulation of epigenetic and transcriptional errors over time, and to aging per se, is largely unknown.
In DECODEM, I aim to analyse cell divisions uncoupled from chronological time, to gain unique insight into the cellular mechanisms underlying aging.We will investigate the exte…
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