CORDIS Project
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This project aims to develop methods for analyzing the genetic and epigenetic diversity within tumors. By separating the contributions of cancerous and normal cells, it seeks to enhance understanding of tumor biology and improve personalized treatment approaches.
Owing to advances in sequencing technology, we are now beginning to understand the molecular mechanisms underlying cancer development and evolution.
Tumours however are heterogeneous, often containing admixed normal cells and different (sub)clones, confounding interpretation of the massive amounts of data flowing from large initiatives such as the International Cancer Genome Consortium.To address this issue, I will develop methods that disentangle tumour bulk gene expression (RNA-Seq) and DNA me…
THE FRANCIS CRICK INSTITUTE LIMITED
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