CORDIS Project
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This project investigates the unique properties of bat influenza A viruses, focusing on their interaction with host cell receptors. It aims to understand the mechanisms that allow these viruses to cross species barriers and replicate effectively.
Influenza A viruses (IAVs) are zoonotic pathogens that frequently cross the species barrier into humans, often causing severe morbidity and even global pandemics.
This cross-species transmission is facilitated in large part by alterations in the interaction between the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) and sialic acid, a ubiquitous glycan that serves as the cellular entry receptor.
Although avian hosts have generally been thought to be the primary reservoir for all…
UNIVERSITAETSKLINIKUM FREIBURG
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