CORDIS Project
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This project explores the role of chromatin modifications in the maintenance and differentiation of human epidermal stem cells. It aims to identify gene expression programs that dictate cell lineage commitment and investigate factors contributing to skin anomalies.
The skin is a multi-layered epithelium consisting of interfollicular epidermis (IFE), hair follicles (HF), sebaceous glands (SG) and apocrine (sweat) glands.
Continuous shedding of terminally differentiated keratinocytes necessitates constant regeneration to ensure tissue homeostasis.
This depends on the epidermal stem cell compartment located on top of the basement membrane.
Several of the signaling pathways involved in this process are known (e.g.
Myc, Wnt, Rac1, Notch, and EGFR) and under inv…
CANCER RESEARCH UK LBG
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