CORDIS Project
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This project explores the role of regulatory T cells in maintaining immune tolerance by suppressing immune responses. It aims to understand the molecular changes in immune cells under T cell suppression and evaluate the therapeutic potential of these changes in treating various diseases.
Regulatory T cells (TREG) comprise a subset of CD4+ T cells that maintain immunological tolerance by suppressing immune activation in a dominant manner. TREG helps shaping the immune responses to autoantigens, alloantigens, tumors, pathogens and allergens, and are thus considered a therapeutical target in a large variety of diseases.
One aspect of TREG biology that remains poorly understood is what molecular program(s) are induced in cells that are being actively suppressed by TREG.
The specifi…
KAROLINSKA INSTITUTET
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