CORDIS Project
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This project investigates the TRIM28 protein's dual roles in transcriptional repression and E3 ubiquitin ligase activity, particularly its regulation by MAGE proteins in cancer cells. Using a multi-disciplinary approach, it aims to elucidate the mechanisms behind TRIM28's functions and interactions, focusing on cellula…
TRIM family proteins are RING-type E3 ubiquitin ligases with important roles in immune responses, autophagy and cellular signalling.
They are characterised by the presence of an N-terminal tripartite motif that harbours the catalytic RING domain and a C-terminal variable substrate-binding domain. TRIM28/KAP1 is a unique family member that is better known for its role in transcriptional repression, which is mediated via its C-terminal PHD-Bromo domains.
Nevertheless, ubiquitination activity has b…
THE FRANCIS CRICK INSTITUTE LIMITED
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