CORDIS Project
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This project aims to engineer human cells by decoding gene regulatory networks to create specific cell types for applications in disease modeling and regenerative medicine. By utilizing advanced single-cell technologies, it seeks to enhance cell maturity and functionality, thereby improving therapeutic interventions.
Human cells engineered in vitro have revolutionized our ability to model human biology and diseases, offering exciting opportunities for therapeutic screening and intervention.
However, single-cell transcriptomics (scRNA-seq) reveals that engineered cells often remain heterogeneous, immature, and dissimilar to primary counterparts.
Precise cell engineering remains challenging without systematic interrogation of gene regulatory networks (GRNs) that establish cell identity.
Here, we propose to eng…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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