CORDIS Project
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This project investigates the degradation of mature messenger RNAs (mRNAs) to understand gene expression regulation. By reconstituting key protein complexes involved in mRNA decay, the research aims to reveal their structural dynamics and interactions, ultimately aiming to recreate the mRNA decay pathway in a laborator…
The degradation of mature mRNAs has emerged as a key step in the regulation of eukaryotic gene expression.
Modulation of the half-life of mRNAs via their degradation is a powerful and versatile mechanism to swiftly alter the expression of proteins in response to changes in physiological conditions.
The decay of mRNAs is performed by a set of macromolecular complexes that act in a sequential and coordinated manner, progressively eroding the ends of the transcript until its degradation is complete…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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