CORDIS Project
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The DE-ORPHAN project aims to identify the physiological functions of orphan peptide receptors, which are crucial drug targets. By developing innovative screening methods and computational tools, the project seeks to discover new compounds that can selectively interact with these receptors, potentially leading to novel…
G protein-coupled receptors make up both the largest membrane protein and drug target families. DE-ORPHAN aims to determine the close functional context; specifically physiological agonists and signaling pathways; and provide the first research tool compounds, of orphan peptide receptors.Determination of physiological agonists (aka de-orphanization), by high-throughput screening has largely failed.
We will introduce a new research strategy: 1) developing highly innovative bioinformatics methods…
KOBENHAVNS UNIVERSITET
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