CORDIS Project
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This project focuses on understanding the DNA-damage response in human cells, which is crucial for repairing DNA lesions that can lead to diseases like cancer. It aims to identify new proteins involved in this response and how they function in cellular processes.
The prime objective for every life form is to deliver its genetic material, intact, to the next generation.
Each human cell receives tens-of-thousands of DNA lesions per day.
These lesions can block genome replication and transcription, and if not repaired or repaired incorrectly, they lead to mutations or wider genome aberrations that threaten cell viability.
To counter such threats, life has evolved the DNA-damage response (DDR), to detect DNA damage, signal its presence and mediate its repair…
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