CORDIS Project
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This project investigates weak protein-protein interactions, specifically focusing on how E3 ubiquitin ligases recognize their substrates through short linear motifs in disordered proteins. By employing innovative techniques, it aims to enhance understanding of these interactions and their role in maintaining genome st…
Weak and transient protein-protein interactions are essential for cellular homeostasis but are challenging to study and therefore incompletely understood.
Many of these interactions involve globular domains that recognize a short linear motif (SLiM) in disordered regions of interacting proteins. E3 ubiquitin ligases frequently use this principle of interaction to recognize their substrates.
The conjugation of ubiquitin chains to a substrate often serves as a signal for degradation by the proteas…
KOBENHAVNS UNIVERSITET
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