CORDIS Project
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This project studies the impact of MYC proteins on the DNA damage response in neuroblastoma. It aims to develop a model that integrates experimental data and mathematical techniques to improve understanding of cancer mechanisms and identify new treatment targets.
Accurate replication of the genome is very important in cells to prevent the propagation of mutations which cause tumour development.
After DNA damage, normal non-cancerous cells arrest the cell cycle in G1 to prevent cell growth until DNA damage is repaired or, if levels of damage are high, cells undergo programmed cell death.
Stress responses leading to a DNA damage response stem from different sources and activate distinct pathways.
However, they converge on the same components of the cell cy…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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