CORDIS Project
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This project aims to understand the mechanisms of dense core vesicle secretion in the brain, which is crucial for neurotransmission and various brain functions. It will investigate the molecular factors involved in vesicle fusion and release, using advanced imaging and genetic techniques.
The regulated secretion of chemical signals in the brain occurs principally from two organelles, synaptic vesicles and dense core vesicles (DCVs).
Synaptic vesicle secretion accounts for the well characterized local, fast signalling in synapses. DCVs contain a diverse collection of cargo, including many neuropeptides that trigger a multitude of modulatory effects with quite robust impact, for instance on memory, mood, pain, appetite or social behavior.
Disregulation of neuropeptide secretion is…
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Netherlands, Amsterdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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