CORDIS Project
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This project investigates the role of a specific type of immune cell, known as CD8alpha+ dendritic cells, in the immune system. By creating genetically modified mice, the research aims to understand these cells' unique functions and their potential applications in immunotherapy for various diseases.
Dendritic cells (DC) are a heterogeneous family of leucocytes with important functions in immunity.
Little is known about the role of distinct DC subtypes in vivo.
In the mouse, a subset known as CD8alpha+ DC has been argued to represent a discrete DC lineage with specialised properties.
These include a superior capacity for presenting exogenous antigens to CD8+ and CD4+ T cells, which makes CD8alpha+ DC an attractive target in vaccination and tolerisation.
However, it is unclear whether CD8alp…
THE FRANCIS CRICK INSTITUTE LIMITED
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