CORDIS Project
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This research focuses on dendritic cells and their role in immune response, specifically how they switch between promoting immunity and tolerance. By studying the IRE1/XBP1 signaling pathway, the project aims to uncover mechanisms that could inform treatments for autoimmune diseases and improve immune responses.
Dendritic cells (DCs) play a crucial role as gatekeepers of the immune system, coordinating the balance between protective immunity and tolerance to self antigens.
What determines the switch between immunogenic versus tolerogenic antigen presentation remains one of the most puzzling questions in immunology.
My team recently discovered an unanticipated link between a conserved stress response in the endoplasmic reticulum (ER) and tolerogenic DC maturation, thereby setting the stage for new insigh…
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