CORDIS Project
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This project explores the development of classical dendritic cells, which are crucial for immune responses. It aims to understand how these cells are generated and how their function is influenced by infections and tissue damage.
Classical dendritic cells (cDCs) are leucocytes that play a key role in innate immunity as well as the initiation and regulation of T cell responses. cDCpoiesis starts with commitment of a bone marrow (BM) haematopoietic progenitor, known as the classical DC precursor (CDP), to the cDC lineage. CDPs then give rise to pre-cDCs that exit the BM via the blood and seed tissues to give rise to the two major types of fully-differentiated cDCs, the cDC1 and cDC2 subsets.
The key parameters of cDCpoiesi…
THE FRANCIS CRICK INSTITUTE LIMITED
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