CORDIS Project
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This research investigates the role of skin dendritic cells in regulating immune responses, particularly in the context of autoimmunity. It aims to understand how these cells influence T-cell behavior and maintain immune balance in the skin.
Tissue immune homeostasis is dependent upon a dynamic balance between effector T-cells (Teff) and regulatory T-cells (Treg).
Biological variables that perturb their ratios are critical determinants in the development of autoimmunity.
How this balance is established and maintained in peripheral tissues is largely unknown and is therefore essential for understanding the pathogenesis of autoimmunity and chronic tissue inflammation.
Current therapies focus on reducing pathogenic Teff responses while…
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