CORDIS Project
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This project investigates the immune functions of dendritic cells, focusing on how DNA exposure during viral infections affects their activity. It aims to uncover the role of specific dendritic cell subsets in antiviral responses and the implications of nuclear envelope rupture on immune activation.
Dendritic cells (DCs) function at the interface between innate and adaptive immunity and have a crucial role in the induction of immune responses.
The goal of this project is to uncover the in vivo functions of two novel molecular mechanisms that were recently identified in vitro in DCs. DCs are rapidly activated when DNA is exposed to the cytosol, which can occur in viral infections.
Recent work has revealed that DNA is also transiently accessible to the cytosol in migrating DCs due to rupture…
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