CORDIS Project
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The project investigates the transcription termination process of RNA polymerase II, crucial for producing functional mRNAs. It employs advanced techniques to explore how pausing of the elongation complex affects gene expression in living cells.
RNA polymerase II (RNAPII) transcribes protein-coding genes in eukaryotes.
The proper RNAPII transcription termination is crucial for generation of functional mRNAs, and then proteins.
Termination, or stop of RNA synthesis, may occur before or after mRNA 3’-end cleavage and polyadenylation.
In the last decade many details have been acquired about mRNA maturation, but still little is known about the termination per se.
In this proposal I will redress this problem.One of the proposed transcription…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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