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The DARWIN project focuses on developing a dual-modality endoscope that combines optical-resolution photoacoustic and fluorescence microscopy. This innovative tool aims to enhance in-vivo imaging capabilities, particularly for studying biological tissues at greater depths.
Photoacoustic imaging, an emerging multi-wave imaging modality that couples light excitation to acoustic detection via the photoacoustic effect (sound generation via light absorption), relies on detecting ultrasound waves that are very weakly scattered in biological tissue.
It provides acoustic-resolution images of optical absorption non-invasively at large depth (up to several cm).
However, ultrasound attenuation increases with frequency, limiting the depth-to-resolution ratio to about 100.
An…
UNIVERSITE GRENOBLE ALPES
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