CORDIS Project
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This project aims to determine the atomic structure of the human shelterin complex using cryo-electron microscopy. By understanding the organization and function of this protein assembly, the research seeks to uncover the molecular mechanisms behind telomere biology and its implications in diseases like cancer and agin…
Telomeres of eukaryotic chromosomes are protected by the shelterin complex.
The human shelterin is a six-subunit protein assembly (TRF1, TRF2, TPP1, POT1, TIN2, Rap1).
This complex associates with telomeric DNA and prevents the mistaken detection of the telomeres as double strand breaks by the DNA Damage Response (DDR) machinery.
Illicit DNA repair at telomeres results in cell cycle arrest and end-to-end chromosomal fusions or other improper recombinations causing genome instability.
The abrogat…
KOBENHAVNS UNIVERSITET
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