CORDIS Project
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The DART project aims to enhance cancer immunotherapy by reprogramming tumor cells into dendritic cells using RNA vectors. This approach seeks to improve T cell activation and immune response against solid tumors, ultimately leading to a scalable and effective treatment option.
Immunotherapy has transformed cancer treatment, but targeting effectively refractory solid tumors remains a challenge due to poor T cell activation.
Downregulation of antigen presentation pathways and lack of professional antigen presenting cells in the tumor microenvironment contribute to immune evasion.
My group has demonstrated direct reprogramming of fibroblasts or tumor cells into type 1 conventional dendritic cells (cDC1) cells by overexpression of the transcription factors PU.1, IRF8, and…
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