CORDIS Project
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The project explores the impact of organelle inheritance on T cell diversity and function during aging. By manipulating organelle dynamics, it aims to rejuvenate T cells, potentially improving immune responses in older adults.
Maintenance of long-lived and quiescent stem cells is impaired during ageing, which negatively impacts tissue regeneration by restricting cell diversity.
In the context of T lymphocytes, ageing is linked to profound changes in their repertoire, which becomes less diverse due to naïve T cell attrition.
This leads to the accumulation of terminally differentiated cells and results in poorer immune responses. I aim to understand whether T cell diversification is fostered by the unequal inheritance o…
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