CORDIS Project
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The D-FENS project investigates the roles of RNA interference in mammals, focusing on the effects of a truncated Dicer on viral infection suppression and oocyte development. By using genetic animal models, the project aims to clarify the relationship between RNAi and other pathways, enhancing our understanding of RNAi'…
Viral infection or retrotransposon expansion in the genome often result in production of double-stranded RNA (dsRNA). dsRNA can be intercepted by RNase III Dicer acting in the RNA interference (RNAi) pathway, an ancient eukaryotic defense mechanism.
Notably, endogenous mammalian RNAi appears dormant while its common and unique physiological roles remain poorly understood. A factor underlying mammalian RNAi dormancy is inefficient processing of dsRNA by the full-length Dicer.
Yet, a simple trunca…
UMG INSTITUTE OF MOLECULAR GENETICS ACA SCIEN CZECH REPU
USTAV MOLEKULARNI GENETIKY AV CR V.V.I.
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SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovakia, Bratislava
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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