CORDIS Project
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This project investigates the role of a specific long non-coding RNA, TERRA, in osteosarcoma cells that utilize a unique telomere maintenance mechanism. It aims to understand how TERRA contributes to inflammation and cancer progression, potentially leading to new therapeutic strategies for this aggressive bone cancer a…
The unlimited replication potential of cancer cells is enabled by their ability to renew their ends of chromosomes, telomeres. A minority of cancers utilizes a recombination pathway, named alternative lenghtening of telomeres (ALT), to maintain their telomeres. ALT cells exhibit increased DNA damage at telomeres and increased levels of TERRA, a lncRNA transcribed from telomeres. TERRA plays important roles in telomere biology, but it also has extranuclear functions.
Short TERRA species were foun…
UNIVERSITA DEGLI STUDI DI TRENTO
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