CORDIS Project
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CYTOMAC investigates how specific transcription factors influence macrophage responses to various cytokines, which are crucial in inflammatory diseases. By leveraging genetic diversity in mouse models, the project aims to uncover novel transcription factors that can lead to more targeted therapies for conditions like r…
Dysregulated macrophage function underlies many inflammatory diseases.
Cytokines, small secreted signaling molecules with immune-modulatory functions, shape the macrophages phenotype, thereby affecting disease states.
Puzzlingly, many cytokines with opposing functions, utilize highly similar JAK-STAT signaling cascades, leaving it unclear how cytokine-specific responses can occur.In my previous work, I studied enhancer activation in mouse macrophages from genetically different strains.
By studyi…
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