CORDIS Project
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This project investigates how macrophages kill bacteria that invade the cytosol, focusing on the role of an antimicrobial peptide called ubiquicidin. It aims to uncover the mechanisms behind the innate immune response and the activation of the Aim2 inflammasome in response to bacterial lysis.
Bacteria replicating within host cells either multiply in membrane-bound compartment or escape into the host cytosol.
The host cytosol has long been considered as a safe haven for bacteria.
However, the host cytosol is armed with an array of innate immune receptors detecting cytosolic invasion.
Furthermore, the macrophage cytosol displays a bacteriolytic activity, which is inducible by IFN.
Surprisingly, the molecular mechanisms of this innate immune effector response are still largely uncharact…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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