CORDIS Project
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This research investigates the mechanics of cell shape changes by studying the interaction between the plasma membrane and the actin cortex. Using innovative microfluidic techniques, it aims to uncover the molecular mechanisms behind cell adhesion and mechanosensing, with implications for understanding diseases like ca…
At the heart of the cell’s ability to maintain its mechanical integrity while dynamically altering its shape is an intimate interaction between plasma membrane and the underlying actin cortex.
There is mounting evidence that regulation of actin–membrane anchoring by lipids and dedicated anchoring proteins is critical for the formation of dynamic actin structures needed for essential functions such as cell division, migration, and mechanosensing.
The underlying mechanisms are difficult to probe,…
STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN
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