CORDIS Project
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This project focuses on developing a new class of small molecules that inhibit cyclophilin D to treat non-alcoholic steatohepatitis (NASH). By optimizing these compounds for oral bioavailability, the project aims to create a viable drug candidate for a disease currently lacking approved therapies.
Non-alcoholic steatohepatitis (NASH) is an increasingly prevalent chronic liver disease (3-4% of the US population) for which there is currently no approved drug therapy.
In the absence of innovative treatments healthcare costs associated with this disease are set to triple over the next decade.
To address this unmet medical need, the pharmaceutical industry is currently pursuing a range of liver fibrosis drug discovery programs based on different mode of actions. A compelling mechanism for trea…
THE UNIVERSITY OF EDINBURGH
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